Home » In Vitro Sensitivity of Meropenem Vs Meropenem with EDTA

In Vitro Sensitivity of Meropenem Vs Meropenem with EDTA

Introduction:

Antimicrobial resistance is a global threat which now a well known matter. Out of which carbapenem resistance is growing which is very alarming. In India it is reported in the range of 12.26 to as high as 26.54%.

Material and Methods:

We performed sensitivity tests using Ezy MIC Strip in 20 consecutive meropenem resistant isolates of Klebsiella, Acinetobactor,Pseudomonas and E. Coli which were grown in standard media and sample taken from urine, sputum, pus, blood and endotracheal tube secretion.

Results and discussion:

In all the 20 samples we tested for Metallobetalactamase presence, 10 are metallobetalactamase positive, 3 are metallobetalactamase negative and remaining 7 are metallobetalactamase non determinate meaning resistance is due to mechanisms other than metallobetalactamases. If you see the MIC values, all are substantially lower in Meropenem plus EDTA than Meropenem alone.

Conclusion:

Clinically if organism is Metallobetalactamase positive,  carbapenem with EDTA can be suggested for clinical use.

References:

  1. K. Nair, Pravin. (2013). Prevalence of carbapenem resistant Enterobacteriaceae from a tertiary care hospital in Mumbai, India. Journal of Microbiology and Infectious Diseases. 03. 207-210. 10.5799/ahinjs.02.2013.04.0110.
  2. https://ccemjournal.com/emergence-of-carbapenem-resistance/

Author:

Dr. Apurba Kumar Borah
Consultant and HOD, Department of Critical Care and Emergency Medicine
Narayana Superspeciality Hospital
Guwahati, Assam

Dr. Vicky Lahkar
Consultant Microbiologist
Narayana Superspeciality Hospital
Guwahati, Assam

Share This Post
Have your say!
50

Customer Reviews

5
0%
4
0%
3
0%
2
0%
1
0%
0
0%

    Leave a Reply

    Your email address will not be published. Required fields are marked *

    You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <s> <strike> <strong>

    Thanks for submitting your comment!