Home » Comparative In Vitro Analysis of Meropenem Vs Biapenem

Comparative In Vitro Analysis of Meropenem Vs Biapenem

Author:

Dr. Apurba Kumar Borah1

Dr. Vicky Lahkar2

Introduction:

Biapenem (1β-methyl-carbapenem) is a newer carbapenem for treatment of infections moderate to severe in nature. It’s stability against most β-lactamases, including AmpC and extended-spectrum β-lactamases (ESBLs), along with a broad spectrum activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria1,2 makes it promising for future. It’s mechanism of action is same as meropenem which binds with penicillin binding proteins and inhibits bacterial cell wall synthesis. The 1-β-methyl group of biapenem makes it more stable against the hydrolysis by human renal dehydropeptidase-I (DHP-I) than is meropenem3.

Material & Methods:

20 isolates were taken randomly from urine, ET (Endotracheal Tube) secretion and sputum. The isolates were tested for the antimicrobial susceptibility of Biapenem by Kirby-Bauer disc diffusion method on Mueller-Hinton Agar media (Hi-Media) and interpreted as per the CLSI guidelines 2023 based on the zone size diameter of Meropenem.

Results:

Out of 20 isolates 8 isolates found to be resistant to both meropenem and biapenem . The rests 12 isolates found to be sensitive to both meropenem and biapenem. Interestingly the sensitivity profile of these 20 isolates found to be completely similar i.e. those sensitive to meropenem are also sensitive to biapenem and those resistant to meropenem also resistant to biapenem. This single centered in vitro study showed non inferiority of biapenem to meropenem.

Discussion:

Carbapenems are excellent bactericidal antimicrobial agents with good tissue penetration and broad spectrum of coverage including gram negative, gram positive and anaerobes. Biapenem has similar antimicrobial profile like meropenem and our study will help in proving evidence that in vitro profile of biapenem is non inferior to meropenem. It is launced in Japan4,5 and so literatures are limited in this agent.

Conclusion:

Our study showed that biapenem is non inferior to meropenem in invitro profile and can be an alternative choice for moderate to severe infections.

  1. Consultant, Critical Care Medicine, Narayana Superspeciality Hospital, Guwahati, Assam, India.
  2. Consultant, Microbiology, Narayana Superspeciality Hospital, Guwahati, Assam, India.

References:

  1. Aldridge KE, Morice N, Schiro DD. In vitro activity of biapenem (L-627), a new carbapenem, against anaerobes. Antimicrob Agents Chemother. 1994;38:889–93. [PMC free article] [PubMed] [Google Scholar]
  2. Bonfiglio G, Maccarone G, Mezzatesta ML, Privitera A, Carciotto V, Santagati M, et al. In vitro activity of biapenem against recent Gram-negative and Gram-positive clinical isolates. Chemotherapy. 1997;43:393–403. [PubMed] [Google Scholar]
  3. Petersen PJ, Jacobus NV, Weiss WJ, Testa RT. In vitro and in vivo activities of LJC10,627, a new carbapenem with stability to dehydropeptidase I. Antimicrob Agents Chemother. 1991;35:203–7. [PMC free article] [PubMed] [Google Scholar]
  4. Nakagawa Y, Suzuki K, Hirose T, Chou T, Fujisawa S, Kida M, et al. Clinical efficacy and safety of biapenem for febrile neutropenia in patients with underlying hematopoietic diseases: a multi-institutional study. J Infect Chemother. 2011;17:58–67. [PubMed] [Google Scholar]
  5. Karino F, Deguchi N, Kanda H, Ohe M, Kondo K, Tada M, et al. Evaluation of the efficacy and safety of biapenem against pneumonia in the elderly and a study on its pharmacokinetics. J Infect Chemother. 2013;19:98–102. [PubMed] [Google Scholar]
Share This Post
Have your say!
60

Customer Reviews

5
0%
4
0%
3
0%
2
0%
1
0%
0
0%

    Leave a Reply

    Your email address will not be published. Required fields are marked *

    You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <s> <strike> <strong>

    Thanks for submitting your comment!